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It is believed that the redox homeostasis in the ER may result in ER-associated stress, which may trigger redox signaling mediators playing roles in ROS formation and consequently in the pathogenesis of various human disorders
However, crashing estrogen too low creates its own problems
3.3 Lipid peroxidation products 3.3.1 Malondialdehyde Lipids are the most impacted biomolecules in oxidative stress-induced damage, and the identification of these end-products in inflammatory diseases suggest that lipid peroxidation is crucial in such diseases (99)
Nat Cell Biol (2014) 16(12):118091
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